International network for natural sciences – research journal
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Y-chromosome polymorphisms in two Pakistani ethnic groups and its relationship with neighbouring Indian populations

By: Muhammad Tariq, Habib Ahmad, Inamullah, Umar Farooq, Tauseef Ahmad

Key Words: Pakistan, Ethnic groups, Y-chromosome, STRs, Haplotypes

Int. J. Biosci. 9(2), 159-163, August 2016.

DOI: http://dx.doi.org/10.12692/ijb/9.2.159-163

Abstract

The paternally inherited Y-chromosome short tandem repeats (Y-STRs), are excellent tool in inferring modern human evolutionary studies, genetic human identification and genetic genealogy. In the present study a total of 60unrelated male of two ethnic groups (Gujarsand Karlars) from Khyber Pakhtunkhwa province of Pakistan were analyzed using PowerPlex®12 Y-STR loci amplification system (DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438 andDYS439), to investigate the genetic polymorphisms and to determine the genetic relationship of two Pakistani populations with three neighboring Indian populations of the same linguistic family. In Gujars a total of 21 haplotypes were identified, 15 of which were unique and 6 haplotype were shared among two or more individuals. The haplotype diversity among Gujars was 0.9701 ± 0.0171, while in Karlars population 19 haplotypes were identified among which 13 were unique haplotypes and 6 were shared among two or more individuals and the observed haplotype diversity value was 0.9563 ± 0.0213.RSTpairwise analysis suggest close genetic relationship between three Indian populations (Andh, Naikpod, Pardhan), while genetically distinct from the two Pakistani Populations (Gujars and Karlars). Results also demonstrate that the 12 Y-STR loci analyzed were highly polymorphic in Gujars and Karlars populations and hence useful for forensic cases and population’s genetic studies.

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