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Synthesis, characterization and biological studies of organotin (iv) complexes of 2H – 1,2,3 – triazole entailing carboxylic acid

By: Aqeela Shaheen, Shahbaz Akhtar, Jameel-ur-Rehman, Saima Anjum, Mujahid Mustaqeem, Aziz-ur-Rehman

Key Words: N-arylation, 6-(1',2',3'-triazol-2'-yl) pyridine-3-carboxylic acid, Carboxylates, Organotin (IV) complexes, Biological studies

Int. J. Biosci. 10(2), 166-178, February 2017.

DOI: http://dx.doi.org/10.12692/ijb/10.2.166-178

Abstract

An efficient and convenient method for the synthesis of 6-(1′,2′,3′-triazol-2′-yl) pyridine-3-carboxylic acid (1) via N-arylation is described. The synthesized azole ligand was further coordinated with a variety of organotin (IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antibacterial, cytotoxic and antiurease activities. Comprehensive biological studies revealed that an aryl group within organotin (IV) moiety, as in compound 8, showed excellent biological activities. While the compound with small alkyl group (compound 5) showed an insignificant inhibition indicating weak interactions at the active sites.

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Synthesis, characterization and biological studies of organotin (iv) complexes of 2H – 1,2,3 – triazole entailing carboxylic acid

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Aqeela Shaheen, Shahbaz Akhtar, Jameel-ur-Rehman, Saima Anjum, Mujahid Mustaqeem, Aziz-ur-Rehman. 2017. Synthesis, characterization and biological studies of organotin (iv) complexes of 2H – 1,2,3 – triazole entailing carboxylic acid. Int. J. Biosci. 10(2), 166-178.
http://dx.doi.org/10.12692/ijb/10.2.166-178
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