Synthesis, characterization and biological activities of cephalosporin metals complexes
By: Rehmat Zaman, Wajid Rehman, Mukhtiar Hassan, Muhammad Mumtaz khan, Zeeshan Anjum, Syed Asad Hussain Shah, Syed Rizwan Abbas
Key Words: Cephalosporin, Syntheses, Characterization, Biological activities
Int. J. Biosci. 9(5), 163-172, November 2016.
Cephalosporin is widely used group prescribed as broad-spectrum antibiotic, containing β-lactam ring. Numerous different bacteriological pathogens are now resistant against cephalosporin due to over use. Subsequently it is necessary to synthesize new derivatives to enhance biological activity against pathogens. In current study cephalosporin were reacted with essential trace elements to synthesize respective metal complexes. The novel compounds were characterized at different spectroscopic techniques like UV, FTIR, HPLC and AAS (atomic absorption spectroscopy). Biological screening of novel compounds was accomplished against diverse group of pathogens. Some of our novel compounds showed high efficacy against the pathogens as compare to parent composites. We have introduced Novel method for ceftriaxone assays at HPLC using simple and safe mobile phase through metal complexation. Toxicity studies were carried out in vitro and with ADMET software. Novel complexes were found less toxic as compare to parent compounds.