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Synthesis and antibacterial activity of Schiff base metal complexes

By: Sheheryar, Zahida Parveen, Taj Ur Rahman, Muhammad Aurang Zeb, Zonera Hassan, Wajid Rehman

Key Words: Schiff base metal complexes, Synthesis, Antibacterial activity, Microorganisms

Int. J. Biosci. 10(6), 259-264, June 2017.

DOI: http://dx.doi.org/10.12692/ijb/10.6.259-264

Abstract

This work was performed to synthesize various Schiff base metal complexes using cobalt, nickel and copper followed by their antibacterial activity. Schiff bases were synthesized by the combination of Ethylene-diam in and salicyldehyde. Metal complexes of these Schiff bases were prepared from nitrate and chloride salts of Ni, Co and Cu in an alcoholic medium. The chemical structures of Schiff base metal complexes were established by infrared spectroscopy. The antimicrobial activities of these complexes were checked against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Bacillus cereus, Salmonella typhiand Staphylococcus aureus. Disc diffusion method was used to assess their inhibiting potential. The copper based Schiff complex displayed 9.5, 9.0 and 8.0mm zone of inhibitions against E. coli, S. typhi and S. aureusat the concentration level of 16.6μg/ 100μL. The results of antibacterial activity of the copper complexes at the concentration of 33.2μg/100μL showed 18.5, 10.5 and 10mm zone of inhibitions against E. coli, S. typhi and S. aureus. The nickel base complex showed no activity against the tested organisms at both concentrations. The cobalt based Schiff complex showed 17,19,22.5 and 26.5 zones of inhibition against E. coli, B. cereus, K. pneumonia and S. aureus, respectively at16.6μg/100μL. While at 33.2μg/ 100μL this complex displayed 23.5, 30.5, 26.5 and 28.5mm zones of inhibition against E. coli, B. cereus, K. pneumonia and S. aureus. These new derivatives may provide a wide choices and flexibility for the development of new, safe and highly active antibiotics.

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Synthesis and antibacterial activity of Schiff base metal complexes

Altun Y, Köseoğlu F. 2006. Solute-solvent interaction effects on protonation equilibrium of substituted N-benzylidene-2-hydroxyanilines in aqueous ethanol: The application of factor analysis to solvatochromic parameters and protonation equilibria. Monatsheftefür Chemie/ Chemical Monthly 137(6), pp.703-716.

Basolo F, Johnson RC. 1965. Coordination Chemistry: The Chemistry of Metal Complexes.

Bell SC, Conklin GL, Childress SJ. 1963. The separation of ketimine isomers. Journal of the American Chemical Society 85(18), pp.2868-2869.

Brand E. 1943. M. Sand berg. Org. Synth., Coll        2, p.49.

Carrico RJ, Densth. HJ., 1973. Mechanism of metal transport across liver cells plasmemembrane. J. Bial, Chem 245, 723.

Das K. 1990. A text book on Medicinal Aspects of Bio-Inorganic chemistry 1st ed., CBS publishers India.

Dwyer FP, Mellar DP. 1964. Chelating Agents and Metal Chelates Aeademic Press  pp. 432.

Hamilton GA, Ribner BS. 1978. Oxidation and antioxident in inorganic chemistry and biology. J.A. Chem Soc 100, 1899.

Hughes MN. 1981. The inorganic chemistry of biological processes 2nd ed., Wiley (Inter Science), New York.

Huheey JE. 1983. Inorganic Chemistry, Principles of Structure and Reactivity 3rd Edn, Harper and Row pp. 917.

Jensen KA, Madson ER, Anorg Z. 1934. Magnetic and spectroscopic properties of CU (II). AllgChem 219, 243.

Johnson CW, Joyner JW, Perry RP. 1952. The inhibitory effect of four thiosemicar bazones on Cryptococcus neofonnans. Antibiotics 2(12), 636-8.

Kirchner S, WeiYK, Francis D, Bergman JG. 1966. Synthesis, characterization and biological activity of Co (II) and Cu (II). J. Med. Chem 9, 369.

McMurray W, Martin VM, Scudder P, Stocks J, White AG, Dormandy TL. 1975. Urinary copper excretion in rheumatoid arthritis. Annals of the rheumatic diseases 34(4), pp.340-345.

Ross PW, Peutherer JF. 1987. Clinical microbiology. Churchill Linvingstpns, UK, Logman Singapore Publisher Ltd. Singapore pp.74.

Schiff H. 1864. Synthesis of Sciiff bases. Ann. Suppl 3, p.343.

Sillen LG, Martell AE. 1971. Stability constants supplement no. 1. Special publication 25, p.865.

Sorenson JRJ, Han garter W. 1977. The role of Cu in inflammatory disorders 2, 21-79.

Sheheryar, Zahida Parveen, Taj Ur Rahman, Muhammad Aurang Zeb, Zonera Hassan, Wajid Rehman.
Synthesis and antibacterial activity of Schiff base metal complexes.
Int. J. Biosci. 10(6), 259-264, June 2017.
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