In vivo anticancer activities of Co(II)-Benzoin Thiosemicarbazone Complex [Co(BTSC)2]

Paper Details

Research Paper 01/10/2016
Views (216) Download (7)
current_issue_feature_image
publication_file

In vivo anticancer activities of Co(II)-Benzoin Thiosemicarbazone Complex [Co(BTSC)2]

Hossain Mohammad Zakir, Md. Khairul Islam, Md. Rakib Hasan, Shaikh M Mohsin Ali, Mele Jesmin
Int. J. Biosci.9( 4), 209-220, October 2016.
Certificate: IJB 2016 [Generate Certificate]

Abstract

Cancer, a diverse group of diseases characterized by the proliferation and spread of abnormal cells, is a major worldwide problem. In order to find out new anticancer drug Co(II) complex with benzoin thiosemicarbazone was synthesized and characterized. Ehrlich Ascites Carcinoma (EAC) cells were used to evaluate the anticancer activities of benzoin thiosemicarbazone complex with Co(II) in swiss albino mice. The anticancer activities were studied by monitoring tumor cell growth inhibition, tumor weight measurement, survival time of tumor bearing swiss albino mice. Hematological parameters of normal and EAC cells bearing treated mice were also studied. The apoptotic cell morphological changes of the treated EAC cells were confirmed by fluorescence and optical microscope. It has been found that the compound enhanced life span, reduced average tumor weight and inhibited tumor cell growth of EAC cell bearing mice remarkably. The results were compared with those obtained with a standard anticancer drug bleomycin. The hematological parameters (WBC, RBC, hemoglobin content and differential counts) were found to be significantly changed as compared to those of the normal mice. These parameters restored more or less towards normal when treated with the test compound.

VIEWS 5

Ali MM, Jesmin M, Mondal S,  Rashed A and Islam K. 2015. In vivo Antineoplastic Activities of Benzoin Thiosemicarbazone and Para-Anisaldehyde Semicarbazone against Ehrlich Ascites Carcinoma Cells. Medical Journal of Islamic World Academy of Sciences 23(4), 131-139.

Ali MM, Jesmin M, Islam MK, Fatema K, Azad KA. 2013. Antineoplastic activities of acetone thiosemicarbazone against Ehrlich ascites carcinoma cells bearing mice. Medical Journal of Islamic World Academy of Sciences 21(3), 97-104.

Ali MM, Azad MAK, Jesmin M, Ahsan S, Rahman MM, Khanam JA, Islam MN, Shahriar SMS. 2012. In vivo anticancer activity of vanillin semicarbazone. Asian Pacific Journal of Tropical Biomedicine 2(6), 438-442. http://dox.doi.org/10.1016/S2221-1691(12)60072-0

Ali MM, Jesmin M, Islam MN, Shahrair SMS, Habib MR, Islam MF. 2009. Anticancer activities of some transition metal complexes of a schiff base derived from salicylaldehyde and glycine. ACGC Chemical Research Communications 23, 13-22.

Abbot BJ. 1976. Bioassay of plant extract for anticancer activity. Cancer Treatment Reports 60, 1007-1017.

Abid AMA, Methak SM, Muna AH. 2011. Preparation and Characterization of some transition metal complexes with new Schiff base ligand derived from benzophenone. Journal of Kufa for Chemical science. NO. (2).

Clarkson BD, Buirchenal JH. 1965. Preliminary screening of antineoplastic drugs. Progress in Clinical Cancer 1, 625-629.

El-Shahawi MS, Al-Jahdali MS, Bashammakh AS, Al-Sibaai AA, Nassef HM. 2013. Spectroscopic and electrochemical characterization of some Schiff base metal complexes containing benzoin moiety. Acta Part A: Molecular and Bimolecular Spectroscopy 113, 459–465. http://dox.doi.org/10.1016/j.saa.2013.04.090

Fernades DJ, Klubes P. 1979. A biochemical and pharmacological study of therapeutic synergism with 5-fluonounacil plus cyclophosphamide in murine L1210   Leukemia. Cancer Research 39, 1396-1404.

Fenninger LD, Mider GB. 1954. Energy and nitrogen metabolism in cancer. Advance Cancer Research 2, 2229-2253. http://dox.doi.org/10.1016/S0065-230X (08)60496-0

Hogland HC. 1982. Hematological complication of cancer chemotherapy. Semin Oncology 9, 95-102.

Hundson L, Hay FC. 1989. Isolation of normal peritoneal macrophages. In practical Immunology, 3rd ed. Black Well Science publisher. Oxford, London, p.26.

Islam K, Ali MM, Jesmin M, Khanam JA. 2012.  In vivo anticancer activities of benzophenone semicarbazone against Ehrlich ascites carcinoma (EAC) cells in swiss albino mice. Cancer Biology and Medicine 9, 242-247. http://dox.doi.org/10.7497/j.issn.20953941.2012.04.004

Jesmin M, Ali MM, Khanam JA. 2010. Antitumor activities of some schiff bases derived from benzoin, salicylaldehyde, amino phenol and 2, 4, dinitrophenyl hydrazine. Thai Journal of Pharmaceutical Sciences 34, 20-31.

Liu MC, Lin TS, Penketh P, Sartorelli AC. 1995. Synthesis and antitumor activity of 4- and 5- substituted derivatives of isoquiniline-1-carboxaldehyde thiosemicarbazone. Journal of Medicinal Chemistry 38(21), 4234-43.

Litehifield JT, Wilcoxon FA. 1949. Simplified method of evaluation dose effects experiment. Journal of Pharmacology and Experimental Therapeutics 96(2), 99-113.

Lee NN, Cadman EC, Michael IN, Michael C, Joseph R, Bertino Farber LR, Prosnitz LR. 1982. Randomized study comparing doxorubicin, cyclophosphamide, vincristine, methotrexate with leucovorin rescue and cytarabine (ACOMLA) with cyclophosphamide, doxorubicin, vincristine, prednisone and bleomycin (CHOP-B) in the treatment of diffuse histiocytic lymphoma. Cancer Treatment Reports 66(6), 1279-1284.

Price VE, Greenfield RE. 1958. Anemia in cancer. Advance Cancer Research 5, 199-200.

Ruisa V, Sood SK. 1988. Routine hematological tests In Medical Laboratory Technology. Mukherjee K J (ed.) Tata McGraw Hill Comp. Ltd. New Delhi, 218.

Shahriar SMS, Ali MM, Jesmin M. 2015. In vivo anticancer activities of vanillin thiosemicarbazone Complexes with Co(II) and Ni(II).Medical Journal of Islamic World Academy of Sciences 23(3), 90-95.

Shahriar SMS, Ali MM, Jesmin M, Islam MK, Mondal S. 2014. In vivo anticancer activity of vanillin, benzophenone and acetophenone thiosemicarbazones on Swiss albino mice. Journal of Coastal Life Medicine 2(10), 811-816. http://dx.doi.org/10.12980/JCLM.2.201414B35