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Hepatoprotective potential of dichloromethan extract of Cassia alata L. (Caesalpiniaceae) leaves from Burkina Faso against carbon tetrachloride-induced hepatic damage in rats

By: Da Filkpièrè Léonard, Obama Pierre, Ouédraogo Youssoufou, Belemtougri Gourounga Raymond, Dimo Théophile

Key Words: Cassia alata, Carbon tetrachloride, Oxidative stress, Enzyme, Hepatoprotective.

Int. J. Biosci. 11(5), 43-53, November 2017.

DOI: http://dx.doi.org/10.12692/ijb/11.5.43-53

Certification: ijb 2017 0128 [Generate Certificate]

Abstract

Cassia alata L. is an herbal plant that has been used as hepatoprotective and anti-inflammatory agent in Burkina Faso medicine. The purpose of this study is to finalize a traditionally improved drug (MTA) that will serve in the treatment of the hepatic disorders. Rats were orally fed with CF-AECal (50 and 100 mg/kg bw) along with administration of CCl4 (20% CCl4/ olive oil; 0.5 ml/kg bw) for 6 weeks.The protection level of hepatic cells by CF-AECal is evaluated by blood rate of SGPT, SGOT, APL and TB and also tissues rate of MDA, GSH, SOD and CAT. This protection rate is observed on the tissues through histological sections.The results showed that the levels of SGPT (12.64 ± 0.25), SGOT (13.13 ± 0.88), ALP (20.39 ± 0.44), TB (12.21 ± 0.30), were significantly increased in CCl4 treated rats when compared with the normal group, but CF-AECal (50 and 100 mg/kg) treated rats showed maximum reduction of SGPT (6.71 ± 0.58 and 6.42 ± 0.49), SGOT (11.25 ± 0.45 and 10.79 ± 0.51), ALP (18.50 ± 0.76 and 16.08 ± 1.49), total bilirubin (10.95 ± 0.62 and 10.36 ± 0.13). Also CF-AECal significantly reduced liver MDA, GSH, SOD and CAT content when compared with control. Histopathological examination of liver sections confirmed that, treatment with CF-AECal decreased the degree of hepatic damage induced by CCl4. Conclusion: these results suggest that the extract of C. alata leaves at various doses protects the rats from CCl4 effects due to its polyphenol and particularly its flavonoids.

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Hepatoprotective potential of dichloromethan extract of Cassia alata L. (Caesalpiniaceae) leaves from Burkina Faso against carbon tetrachloride-induced hepatic damage in rats

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Da Filkpièrè Léonard, Obama Pierre, Ouédraogo Youssoufou, Belemtougri Gourounga Raymond, Dimo Théophile.
Hepatoprotective potential of dichloromethan extract of Cassia alata L. (Caesalpiniaceae) leaves from Burkina Faso against carbon tetrachloride-induced hepatic damage in rats.
Int. J. Biosci. 11(5), 43-53, November 2017.
http://www.innspub.net/ijb/hepatoprotective-potential-dichloromethan-extract-cassia-alata-l-caesalpiniaceae-leaves-burkina-faso-carbon-tetrachloride-induced-hepatic-damage-rats/
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