Evaluation of direct in-vitro effect of Vaccinium macrocarpon against E. coli in urinary tract infection patients
By: Sardar Riaz-Ul-Hassan, Zeeshan Anjum, Nazia Malik, Lubna Shakir, Ghazanfar Ali
Key Words: Cranberry, UTI, Urinary tract infection, E. coli
Int. J. Biosci. 9(6), 440-445, December 2016.
Cranberry extract is a famous crude drug used in urinary tract infection all over the world and research is being carried out on its different aspects in urinary tract infection treatment. In patient with recurrent urinary tract infection and prophylaxis use of anti-microbial is required for prolong period. It is an effective way but on the cost of adverse effects and increasing resistance among uro-pathogens has pursued the researchers to dig out other alternative anti-microbial agents for treatment of recurrent urinary tract infection. This fact has created interest in Cranberry (Vaccinium macrocarpon) for its use in recurrent urinary tract infection. One hundred patients from two hospitals were studied. Using well diffusion method E. coli resistance against Cranberry was checked in-vitro. E. coli showed resistance against CB extract powder in both centers. Cranberry has no direct effect on E. coli but its effectiveness in urinary tract infection along with antibiotics is due to its anti-motility, anti-adherence effects.