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Assessment of coagulation abnormalities associated with liver diseases

By: Sher Bacha, Abid Ul Ghafoor, Hashmat Ullah Khan, Ali, Eiman Sumayyah, Sahib Zada, Tahir Khan, Nikhat Ilahi, Suliman Khan, Wasim Sajjad

Key Words: Coagulation abnormalities, Liver diseases, Gastrointestinal bleeding.

Int. J. Biosci. 11(6), 89-99, December 2017.

DOI: http://dx.doi.org/10.12692/ijb/11.6.89-99

Certification: ijb 2017 0164 [Generate Certificate]

Abstract

Coagulation abnormalities in patients with liver diseases occur frequently. The disorders include, changes in procoagulant factors, natural anticoagulant factors, fibrinolytic, antifibrinolytic, inhibitors of coagulation factors, endothelial dysfunction, thrombocytopenia and thrombocytopathy disturbing the normal hemostatic balance, results in different clinical conditions from abnormal bleeding to thrombosis. This study was aimed to assess the coagulation abnormalities associated with liver diseases. Routine coagulation tests such as Prothrombin Time, Activated Partial Thromboplastin Time and Platelet count were carried out for all patients. Data and samples of 278 patients admitted in Gastroenterology Ward of Hayatabad Medical Complex Peshawar (excluding patients with congenital coagulation disorders). Patients with prolonged PT= 91.7%, (mean value 28.6 ± 15.1 sec), with cumulative percentage of patients with International Normalized Ratio=3 was 78%, prolonged APTT= 88%, with (mean value = 50.6 ± 19 sec), Prolonged PT and APTT both= 84.9%, low platelet count= 59%. No significant difference was found between male and female patients regarding coagulation disorder. Patients with gastrointestinal bleeding were 13%.The study concluded that most of the patients were at risk for abnormal bleeding or thrombo-embolism. These patients would need prophylaxis before going through surgery and would need special care after any trauma or injury.

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Assessment of coagulation abnormalities associated with liver diseases

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Sher Bacha, Abid Ul Ghafoor, Hashmat Ullah Khan, Ali, Eiman Sumayyah, Sahib Zada, Tahir Khan, Nikhat Ilahi, Suliman Khan, Wasim Sajjad.
Assessment of coagulation abnormalities associated with liver diseases.
Int. J. Biosci. 11(6), 89-99, December 2017.
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