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Antifungal activity of Vanillin, Benzophenone, Acetophenone Thiosemicarbazones and their Cobalt (II) and Nickel (II) complexes

By: Sha Md. Shahan Shahriar, Hossain Mohammad Zakir, Mele Jesmin, Shaikh Mohammad Mohsin Ali

Key Words: Antifungal activity, Minimal fungicidal concentration, Schiff bases, Schiff base complexes

Int. J. Biosci. 12(1), 111-118, January 2018.

DOI: http://dx.doi.org/10.12692/ijb/12.1.111-118

Certification: ijb 2018 0192 [Generate Certificate]

Abstract

Since the prehistoric times fungal infections are one of the most common diseases known to humanity and mortality due to these infections even with antifungal therapy is still unacceptably high. Therefore, the development of new antifungal agents targeting specific fungal structures or functions is being actively pursued. The antifungal activity of three schiff bases (vanillin thiosemicarbazone, benzophenone thiosemicarbazone and acetophenone thiosemicarbazone) and two schiff base complexes vanillin thiosemicarbazone with Ni(II) and Co(II) were studied against some fungus (Candida albicans, Aspergillus niger, Aspergillus flavus, Aspergillus fumigates and Mucor sp.) by disc diffusion method. The antifungal activity was compared with the standard drug nystatin. Both schiff bases and schiff base complexes showed significant antifungal activity against all test organisms. But among all the experimental compounds the activity of vanillin thiosemicarbazone with Ni (II) against all test organisms was quite comparable with that of standard drug nystatin at dose 100µg/disc. Other four compounds vanillin thiosemicarbazone, benzophenone thiosemicarbazone, acetophenone thiosemicarbazone and vanillin thiosemicarbazone with Co (II) showed moderate activity. Among all schiff bases, VTS showed highest zone of inhibition (27±1.2 mm) against Candida albicans at dose 200µg/disc. For schiff base complexes, the highest zone of inhibition was found for NVTS (23±0.9 mm) against Mucor sp. at dose 200µg/disc. Better results were obtained with high doses. All these synthesized compounds were found to possess cytotoxic effect. Minimal fungicidal concentration of these compounds was also determined. It is concluded that these compounds are biologically active and can be primarily considered as potent antifungal agents.

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Antifungal activity of Vanillin, Benzophenone, Acetophenone Thiosemicarbazones and their Cobalt (II) and Nickel (II) complexes

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Sha Md. Shahan Shahriar, Hossain Mohammad Zakir, Mele Jesmin, Shaikh Mohammad Mohsin Ali.
Antifungal activity of Vanillin, Benzophenone, Acetophenone Thiosemicarbazones and their Cobalt (II) and Nickel (II) complexes.
Int. J. Biosci. 12(1), 111-118, January 2018.
http://www.innspub.net/ijb/antifungal-activity-vanillin-benzophenone-acetophenone-thiosemicarbazones-cobalt-ii-nickel-ii-complexes/
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