A Review of Cinnamon as antioxidant in the amelioration of oxidative stress related disorders

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Review Paper 01/02/2017
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A Review of Cinnamon as antioxidant in the amelioration of oxidative stress related disorders

Muhammad Saleem Asghar, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Wajid, Zahid Farooq, Safdar Javed, Raza Ahmad, Muhammad Saleem Khan
Int. J. Biosci.10( 2), 89-99, February 2017.
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Abstract

Cinnamon is often known as plant of tropical medicine. Its bark is commonly used as a spice in cooking on the daily basis around the world. It also has beneficial medicinal characteristics in the prevention or treatment of different chronic diseases. It is beneficial in oxidative stress, controlling the blood glucose level, blood pressure, blood lipids, and insulin sensitivity. It is used as powdered form, aqueous extract and essential oil. A number of cinnamon constituents have been isolated and are considered responsible for positive health effects. In this article, a brief review of several studies on cinnamon, its constituents and their potential medical uses are critically explained.

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Abd El-Aziz AR, Mahmoud MA, Al-Othman MR, Al-Gahtani MF. 2015. Use of Selected Essential Oils to Control Aflatoxin Contaminated Stored Cashew and Detection of Aflatoxin Biosynthesis Gene. The Scientific World Journal 2015, 1-13. http://dx.doi. org/10.1155/2015/958192.

Asghar MS, Quershi NA, Jabeen F, Shakeel M, Khan MS. 2016. Genotoxicity and oxidative stress analysis in the Catla catla treated with ZnO NPs. Journal of Biodiversity and Environmental Sciences 8(4), 91-104.

Assadollahi V, Gholami M, Zendedel A. 2014. C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1). Bratislavske lekarske listy 116(2), 132-135. http:// dx.doi.org/10.4149/bll_2015_026.

Bandara T, Uluwaduge I, Jansz E. 2012. Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. International Journal of Food Sciences and Nutrition 63(3), 380-386. http://dx.doi.org/10.3109/09637486.2011.627849.

Barceloux DG. 2009. Cinnamon (Cinnamomum species). Disease-a-month 55(6), 327-335. http://dx.doi.org/10.1016/j.disamonth.2009.03.003.

Becerril R, Gómez-Lus R, Goni P, López P, Nerín C. 2007. Combination of analytical and microbiological techniques to study the antimicrobial activity of a new active food packaging containing cinnamon or oregano against E. coli and S. aureus. Analytical and bioanalytical chemistry 388(5-6), 1003-1011. http://dx.doi.org/10.1007/s00216-007-1332-x.

Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. 2007. Effect of cinnamon on glucose and lipid levels in Non–insulin-dependent type 2 diabetes. Diabetes care 30(9), 2236-2237. http://dx.doi.org/10.2337/dc07-0098.

Bonifati V, Oostra BA, Heutink P. 2004. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson’s disease. Journal of molecular medicine 82(3), 163-174. http://dx.doi.org/10.1007/s00109-003-0512-1.

Brahmachari S, Jana A, Pahan K. 2009. Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. The Journal of Immunology 183(9), 5917-5927. http://dx.doi.org/10.4049/ jimmunol.0803336.

Buru AS, Pichika MR, Neela V, Mohandas K. 2014. In vitro antibacterial effects of Cinnamomum extracts on common bacteria found in wound infections with emphasis on methicillin-resistant Staphylococcus aureus. Journal of ethnopharmacology 153(3), 587-595. http://dx.doi.org/10.1016/j.jep.2014.02.044.

Cheng S-S, Liu J-Y, Tsai K-H, Chen W-J, Chang S-T. 2004. Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. Journal of agricultural and food chemistry 52(14), 4395-4400. http://dx.doi.org/10.1021/jf0497152.

Chou ST, Chang WL, Chang CT, Hsu SL, Lin YC, Shih Y. 2013. Cinnamomum cassia essential oil inhibits α-MSH-induced melanin production and oxidative stress in murine B16 melanoma cells. International journal of molecular sciences 14(9), 19186-19201. http://dx.doi.org/10.3390/ijms140919186.

Civitello L. 2011. Cuisine and culture: A history of food and people: John Wiley & Sons.

Crawford TN, Alfaro I, Kerrison JB, Jablon EP. 2009. Diabetic retinopathy and angiogenesis. Current diabetes reviews 5(1), 8-13.

Dhulasavant V, Shinde S, Pawar M, Naikwade N. 2010. Antihyperlipidemic activity of Cinnamomum tamala Nees. on high cholesterol diet induced hyperlipidemia. International Journal of PharmTech Research 2(4), 2517-2521.

Du Y-H, Feng R-Z, Li Q, Wei Q, Yin Z-Q, Zhou L-J, Tao C, Jia R-Y. 2014. Anti-inflammatory activity of leaf essential oil from Cinnamomum longepaniculatum (Gamble) N. Chao. International journal of clinical and experimental medicine 7(12), 5612.

ElBassossy HM, AboWarda SM, Fahmy A. 2013. Chrysin and Luteolin Attenuate Diabetes‐Induced Impairment in Endothelial‐Dependent Relaxation: Effect on Lipid Profile, AGEs and NO Generation. Phytotherapy Research 27(11), 1678-1684. http://dx.doi.org/10.1002/ptr.4917.

Fang S-H, Rao YK, Tzeng Y-M. 2004. Cytotoxic effect of trans-cinnamaldehyde from Cinnamomum osmophloeum leaves on Human cancer cell lines. International Journal of Applied Science and Engineering 2(2), 136-147.

Fratini F, Casella S, Leonardi M, Pisseri F, Ebani VV, Pistelli L, Pistelli L. 2014. Antibacterial activity of essential oils, their blends and mixtures of their main constituents against some strains supporting livestock mastitis. Fitoterapia 96, 1-7. http://dx.doi.org/10.1016/j.fitote.2014.04.003.

Gende LB, Floris I, Fritz R, Eguaras MJ. 2008. Antimicrobial activity of cinnamon (Cinnamomum zeylanicum) essential oil and its main components against Paenibacillus larvae from Argentine. Bulletin of insectology 61(1), 1.

Goni P, López P, Sánchez C, Gómez-Lus R, Becerril R, Nerín C. 2009. Antimicrobial activity in the vapour phase of a combination of cinnamon and clove essential oils. Food chemistry 116(4), 982-989. http://dx.doi.org/10.1016/j.foodchem.2009.03.058.

Gunawardena D, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G. 2015. Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts–identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds. Food & function 6(3), 910-919. http://dx.doi.org/10.1039/ c4fo00680a.

Gunawardena K, Murray DK, Swope RE, Meikle AW. 2002. Inhibition of nuclear factor κB induces apoptosis following treatment with tumor necrosis factor α and an antioxidant in human prostate cancer cells. Cancer detection and prevention 26(3), 229-237. http://dx.doi.org/10.1016/s0361-090x(02)00061-2.

Gupta C, Kumari A, Garg AP. 2012a. Comparative study of cinnamon oil and clove oil in some oral microbiota. Acta Bio Medica Atenei Parmensis 82(3), 197-199.

Hong J-W, Yang G-E, Kim YB, Eom SH, Lew J-H, Kang H. 2012. Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC complementary and alternative medicine 12(1), 237. http://dx.doi.org/10.1186/1472-6882-12-237.

Hossein N, Zahra Z, Abolfazl M, Mahdi S, Ali K. 2013. Effect of Cinnamon zeylanicum essence and distillate on the clotting time. Journal of Medicinal Plants Research 7(19), 1339-1343.

Huang T-C, Fu H-Y, Ho C-T, Tan D, Huang Y-T, Pan M-H. 2007. Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells. Food chemistry 103(2), 434-443.

Hwa JS, Jin YC, Lee YS, Ko YS, Kim YM, Shi LY, Kim HJ, Lee JH, Ngoc TM, Bae KH. 2012. 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. Journal of ethnopharmacology 139(2), 605-615. http://dx.doi.org/10.1016/j.jep.2011.12.001.

Jakhetia V, Patel R, Khatri P, Pahuja N, Garg S, Pandey A, Sharma S. 2010. Cinnamon: a pharmacological review. Journal of advanced scientific research 1(2), 19-23.

Jana A, Modi KK, Roy A, Anderson JA, van Breemen RB, Pahan K. 2013. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. Journal of Neuroimmune Pharmacology 8(3), 739-755. http://dx.doi.org/10.1007/s11481-013-9447-7.

Jeong H-W, Han DC, Son K-H, Han MY, Lim J-S, Ha J-H, Lee CW, Kim HM, Kim H-C, Kwon B-M. 2003. Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G 2/M phase. Biochemical Pharmacology 65(8), 1343-1350. http://dx.doi.org/10.1016/s0006-2952(03)00038-8.

Kandhare AD, Bodhankar SL, Singh V, Mohan V, Thakurdesai PA. 2013. Anti-asthmatic effects of type-A procyanidine polyphenols from Cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals. Biomedicine & Aging Pathology 3(1), 23-30. http://dx.doi.org/10.1016/j.biomag. 2013.01.003.

Khalid N, Ahmed I, Latif MSZ, Rafique T, Fawad SA. 2014. Comparison of antimicrobial activity, phytochemical profile and minerals composition of garlic Allium sativum and Allium tuberosum. Journal of the Korean Society for Applied Biological Chemistry 57(3), 311-317 http://dx.doi. org/10.1007/s13765-014-4021-4.

Khan FU, Rahool, Nangyal B, Nangyal H, Khan MS. 2016. Changes in cardiac troponin level in Myocardial infracted patients and its relation with age. International Journal of Biosciences 9(2), 97-103. http://dx.doi.org/10.12692/ijb/9.2.96-103.

Khan MS, Jabeen F, Asghar MS, Qureshi NA, Shakeel M, Noureen A, Shabbir S. 2015. Role of nao-ceria in the amelioration of oxidative stress: current and future applications in medicine. International Journal of Biosciences (IJB) 6(8), 89-109. http://dx.doi.org/10.12692/ijb/6.8.89-109.

Khan MS, Jabeen F, Qureshi NA, Asghar MS, Shakeel M, Noureen A. 2015a. Toxicity of silver nanoparticles in fish: a critical review. Journal of Biodiversity and Environmental Sciences 6(5), 211-227.

Khan MS, Quershi NA, Jabeen F, Asghar MS, Shakeel M. 2016. Analysis of minerals profile, phenolic compounds and potential of Garlic (Allium sativum) as antioxidant scavenging the free radicals. International Journal of Biosciences 8(4), 72-82. http://dx.doi.org/10.12692/ijb/8.4.72-82.

Khan MS, Qureshi NA, Jabeen F, Asghar MS, Shakeel M, Fakhar -e -Alam M. 2016b. Eco-Friendly Synthesis of Silver Nanoparticles Through Economical Methods and Assessment of Toxicity Through Oxidative Stress Analysis in the Labeo Rohita. Biological trace element research, 1-13. http://dx.doi.org/10.1007/s12011-016-0838-5.

Khan MU, Qurashi NA, Khan MS, Jabeen F, Umar A, Yaqoob J, Wajid M. 2016. Generation of reactive oxygen species and their impact on the health related parameters: A critical review. International Journal of Biosciences 9(1), 303-323. http://dx.doi.org/10.12692/ijb/9.1.303-323.

Khasnavis S, Pahan K. 2012. Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. Journal of Neuroimmune Pharmacology 7(2), 424-435. http://dx.doi.org/10.1007/s11481-011-9286-3.

Kong B, Wang J, Xiong YL. 2007. Antimicrobial activity of several herb and spice extracts in culture medium and in vacuum-packaged pork. Journal of Food Protection® 70(3), 641-647. http://dx.doi.org/10.4315/0362-028x-70.3.641.

Kongstad KT, Özdemir C, Barzak A, Wubshet SG, Stærk D. 2015. Combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR for investigation of antidiabetic principles in crude plant extracts. Journal of agricultural and food chemistry 63(8), 2257-2263. http://dx.doi.org/ 10.1021/jf506297k.

Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R. 2010. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC cancer 10(1), 210. http://dx.doi.org/10.1186/1471-2407-10-210.

Kwon B-M, Lee S-H, Cho Y-K, Bok S-H, So S-H, Youn M-R, Chang S-I. 1997. Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters 7(19), 2473-2476. http://dx.doi. org/10.1016/s0960-894x(97)10008-7.

Kwon H-K, Jeon WK, Hwang J-S, Lee C-G, So J-S, Park J-A, Ko BS, Im S-H. 2009. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. Cancer letters 278(2), 174-182. http://dx.doi. org/10.1016/j.canlet.2009.01.015.

Lee R, Balick MJ. 2005. Sweet wood cinnamon and its importance as a spice and medicine. Explore: The Journal of Science and Healing 1(1), 61-64. http://dx.doi.org/10.1016/j.explore.2004.10.011.

Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, Oh KW, Han DC, Kwon BM, Hong JT. 2005. Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-κB activation in RAW 264.7 cells. Biochemical Pharmacology 69(5), 791-799. http://dx.doi.org/10. 1016/j.bcp.2004.11.013.

Lu J, Zhang K, Nam S, Anderson RA, Jove R, Wen W. 2010. Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis 31(3), 481-488. http://dx.doi.org/10.1093/carcin/bgp292.

MA J-H, NIE J-H, XING J-H. 2006. Optimization for extraction process of cortex phellodendri [J]. Journal of Xinjiang Medical University 4, 003.

Manosi S, Mandal S, Mallick B, Hazra J. 2013. Ethnobotany, Phytochemical and pharmacological aspect of Cinnamomum Zeylanicum. int. Res. International Research Journal of Pharmacy 4, 58-63. http://dx.doi.org/10.7897/2230-8407.04409.

Marongiu B, Piras A, Porcedda S, Tuveri E, Sanjust E, Meli M, Sollai F, Zucca P, Rescigno A. 2007. Supercritical CO2 extract of Cinnamomum zeylanicum: chemical characterization and antityrosinase activity. Journal of agricultural and food chemistry 55(24), 10022-10027. http://dx.doi.org/10.1021/jf071938f.

Minich S, Msom L. 2008. Chinese Herbal Medicine in Women’s Health. Women’s Health.

Mohammadi A, Oshaghi EA. 2014. Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice. Journal of Diabetes Metabolic Disorder 13(1), 20.

Najafi S, Taherpour K. 2014. Effects of Dietary Ginger (Zingiber Ofjicinale), Cinnamon (Cinnamomum), Synbiotic and Antibiotic Supplementation on Performance of Broilers. Journal of Animal Science Advances 4(1), 658-667.

Panickar K, Polansky M, Graves D, Urban J, Anderson R. 2012. A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemia-like injury in vitro. Neuroscience 202, 87-98. http://dx.doi.org/10.1016/j.neuroscience.2011.11.051.

Parthasarathy H, Thombare S. 2013. Evaluation of antimicrobial activity of Azadirachta indica, Syzygium aromaticum and Cinnamomum zeyalnicum against oral microflora. Asian Journal of Experimental Sciences 27(2), 13-16.

Peng L, He X, Zhang P, Zhang J, Li Y, Zhang J, Ma Y, Ding Y, Wu Z, Chai Z. 2014. Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size. International journal of molecular sciences 15(4), 6072-6085.

Peterson DW, George RC, Scaramozzino F, LaPointe NE, Anderson RA, Graves DJ, Lew J. 2009. Cinnamon extract inhibits tau aggregation associated with Alzheimer’s disease in vitro. Journal of Alzheimer’s Disease 17(3), 585.

Qin B, Polansky M, Anderson R. 2010. Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructose-fed rats. Hormone and metabolic research= Hormon-und Stoff wechselforschung= Hormones et metabolisme 42(3), 187-193. http://dx.doi.org/10.1055/s-0029-1242746.

Rao PV, Gan SH. 2014. Cinnamon: a multifaceted medicinal plant. Evidence-Based Complementary and Alternative Medicine 2014.

Rao R, Møller IM. 2011. Pattern of occurrence and occupancy of carbonylation sites in proteins. Proteomics 11(21), 4166-4173. http://dx.doi.org/ 10.1002/pmic.201100223.

Sartorius T, Peter A, Schulz N, Drescher A, Bergheim I, Machann J, Schick F, Siegel-Axel D, Schurmann A, Weigert C. 2014. Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PloS one 9(3). http://dx.doi.org/10.1371/journal.pone.0092358.

Shobana S, Naidu KA. 2000. Antioxidant activity of selected Indian spices. Prostaglandins, Leukotrienes and Essential Fatty Acids 62(2), 107-110. http://dx.doi.org/10.1054/plef.1999.0128.

Singh TS, Mitra S. 2007. Fluorescence behavior of intramolecular charge transfer state in trans-ethyl p-(dimethylamino) cinamate. Journal of Luminescence 127(2), 508-514. http://dx.doi.org/10.1016/j.jlumin. 2007.03.001.

Song F, Li H, Sun J, Wang S. 2013. Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. Journal of Ethnopharmacology 150(1), 125-130. http://dx.doi.org/10.1016/j.jep.2013.08.019.

Suhaj M, Rácová J, Polovka M, Brezová V. 2006. Effect of γ-irradiation on antioxidant activity of black pepper (Piper nigrum L.). Food chemistry 97(4), 696-704. http://dx.doi.org/10.1016/j. foodchem.2005.05.048.

Timotius KH, Sari IN, Santoso AW. 2015. Major Bioactive Compounds of Pilis Plant Materials: A GC-MS Analysis. http://dx.doi.org/10.5530/pc.2015.3.4.

Tung Y-T, Yen P-L, Lin C-Y, Chang S-T. 2010. Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharmaceutical biology 48(10), 1130-1136. http://dx.doi.org/10.3109/13880200903527728.

Urbaniak A, Głowacka A, Kowalczyk E, Lysakowska M, Sienkiewicz M. 2013. The antibacterial activity of cinnamon oil on the selected gram-positive and gram-negative bacteria. Medycyna doswiadczalna i mikrobiologia 66(2), 131-141.

Vangalapati M, Satya S, Prakash S, Avanigadda S. 2012. A review on pharmacological activities and clinical effects of Cinnamon species. Research Journal of pharmaceutical, biological and chemical sciences 3(1), 653-663.

Wang HP, Yang J, Qin LQ, Yang XJ. 2015. Effect of Garlic on Blood Pressure: A Meta‐Analysis. The Journal of Clinical Hypertension 17(3), 223-231. http://dx.doi.org/10.1111/jch.12473.

Yeh H-F, Luo C-Y, Lin C-Y, Cheng S-S, Hsu Y-R, Chang S-T. 2013. Methods for thermal stability enhancement of leaf essential oils and their main constituents from indigenous cinnamon (Cinnamomum osmophloeum). Journal of agricultural and food chemistry 61(26), 6293-6298.